By Sanford Brnham Prebys

This month, researchers participating in the Cilento Initiative on Aging Outcomes or CIAO study will gather in Acciaroli (Pollica-Cilento) Salerno, Italy to review a decade of work and plan their next steps. Launched in 2016, the CIAO study seeks to identify key factors (biological, psychological and social) that promote healthy aging and extreme longevity.

The Natural Park of Cilento region in southern Italy is home to roughly 300 residents who are more than100 years old and in robust health. The broader region is notable for the long lives of its residents. It was the original source of research for Ancel Keys, the American physiologist who studied the influence of diet on health and first promoted the benefits of the Mediterranean diet.

Scientists hope to reveal the longevity secrets of the Cilento region using an array of tools to measure metabolomics, biomes, cognitive dysfunction and protein biomarkers for risk of heart disease, Alzheimer’s, kidney disease and cancer, along with psychological, social and lifestyle surveys.

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