Five Hallmarks of Stem Cell Aging Proposed

By josh Conway – Lifespan Research Institute –

Like the Hallmarks of Aging, these five are deeply intertwined.

• This review proposes five aging hallmarks specific to stem cells.
• These hallmarks measure how cells operate and function.
• They can increase or decrease in different contexts and different tissues.

This review begins with a note that its classifications focus on the physical features and overall behavior rather than what is going on biochemically. This is because the hallmarks of aging are largely universal across cells; things such as genomic instability, epigenetic alterations, mitochondrial dysfunction, and loss of proteostasis affect every cell in the body, not just stem cells. Additionally, these molecular markers vary greatly across cells; while these will surely have to be dealt with in future work targeting individual populations, these reviewers are endeavoring to deliver a broad understanding rather than a detailed analysis.

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