by Josh Conway – Lifespan Research Institute –
Compounds that affect transcription were identified.
Researchers have developed a transcription-based clock that estimates brain age and used it to identify potential interventions against age-related neurodegeneration.
Deciding which -omic to use
While neurodegeneration and brain aging are not precisely the same [1], the two are tightly linked [2]. Substantial previous work has found that directly addressing brain aging in multiple forms, including the use of Yamanaka factors to facilitate epigenetic rejuvenation, leads to better outcomes in models [3]. However, finding the right approaches, particularly approaches that can be safely and effectively administered to human beings, has proven difficult.
