By Tarun Sai Lomte – Medical and Life Sciences News –
In a recent study published in the journal Cell Reports, researchers characterized CD4 cytotoxic T lymphocytes (CD4 CTLs) in supercentenarians.
Aging is marked by a gradual functional decline, driven by cellular and molecular alterations, including cellular senescence, DNA mutations, and mitochondrial dysfunction. Supercentenarians, people aged 110 or older, provide a model of healthy aging, attaining longevity while delaying or avoiding age-related diseases, e.g., cancer and cardiovascular disease. Their epigenomic, immune, and cardiovascular profiles appear younger for their age.
