by Kerstin Wagner, Leibniz Institute on Aging – Fritz Lipmann Institute – MedicalXpress –
As we age, the composition and function of proteins in the brain change, affecting how well our brain performs later in life—influencing memory, responsiveness, and the risk of neurodegenerative diseases.
An international research team led by Dr. Alessandro Ori from the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena has now discovered that a specific chemical modification, known as ubiquitylation, plays a crucial role in these processes. This modification determines which proteins remain active and which are targeted for degradation.
The findings have been published in Nature Communications.
