The cells regained many of their lost capabilities.
by Arkadi Mazin – Lifespan.io
Using a novel senolytic drug, scientists have successfully eliminated senescent cells in human skin transplanted into mice. The treatment led to prolonged skin rejuvenation.
Senescence and senolytics
Senescent cells, also known as “zombie cells”, are cells that have stopped proliferating after being subjected to any of several types of stress (replicative, chemical, radiational, etc.) but evade clearance by the immune system. Such cells secrete the senescence-associated secretory phenotype (SASP), a cocktail of mostly harmful molecules that harm neighboring cells, driving more of them towards senescence and promoting inflammation. Cellular senescence is one of the hallmarks of aging.
