By Ava Durgin – mindbodygreen –

If you’re in your 30s or 40s and starting to notice subtle changes—sleep that’s not quite as restorative, mood shifts, or cycles that suddenly feel unpredictable—you might be entering perimenopause, the hormonal transition leading up to menopause.

And according to a massive new study presented at the 2025 Annual Meeting of The Menopause Society, this stage might be the most powerful window for protecting your long-term health with hormone therapy.

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