By Anna Drangowska-Way – Lifespan.io –
In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations, improvements in behavior and ability, and reduced fearfulness.
In this new study, the researchers used four-month-old mice of two different strains, senescence-accelerated mouse prone 8 (SAMP8), a mouse strain used as a model of age-related cognitive decline and, as a control, senescence-accelerated mouse resistant 1 (SAMR1), a strain that ages normally.
A group of 15 SAMP8 mice received HUCMSCs weekly for eight weeks. Additionally, researchers had SAMP8 and SAMR1 groups that didn’t receive HUCMSCs as a control. One week following the end of the experiment, the researchers took fecal and blood samples from now 6-month-old mice.
