by University of Tsukuba – Technology Networks –
A protein in the blood may reveal how fast we age and help explain why some families live longer.
Aging is a systemic process that affects the entire body. Visible external signs of aging usually correspond to evidence of equivalent aging in the functioning of their internal organs. This indicates that skin cells age in tandem with other cells throughout the body, suggesting a mechanism whereby aging in one part of the body spreads systemically.
The Tsukuba research group began focusing on CtBP2 while working to elucidate the mechanisms responsible for obesity. This sensor molecule is known to respond to metabolism, and its activity has previously been reported to decrease in individuals with obesity, leading to metabolic syndrome. Furthermore, the activation of CtBP2 has demonstrated therapeutic effects. The Tsukuba researchers conducted a detailed study of the molecular mechanisms of CtBP2. They found that this molecule, which was previously thought to work inside the cell, is secreted extracellularly when activated. They found that activation improves systemic metabolism and that disruption of this process leads to aging and an increase in health problems. This is in concordance with the simultaneous nature of the aging process throughout the whole body.
