by The Korea Advanced Institute of Science and Technology (KAIST) – Phys.org –
As aging progresses, the quality of DNA and proteins inside cells declines, which is known to be the cause of various degenerative diseases. However, the connection between aging and RNA has remained largely unexplored.
Now, a Korean research team has discovered that a ribosome-associated quality control factor—PELOTA, a protein essential for eliminating abnormal mRNA—plays a central role in slowing aging and promoting longevity. This breakthrough, published in the Proceedings of the National Academy of Sciences, is expected to provide a new direction for future therapeutic strategies targeting human aging and neurodegenerative diseases.
