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Scientists have identified platelet factor 4 (PF4), produced by platelets, as the shared mechanism enhancing cognitive function in young blood transfusion, the longevity hormone klotho, and exercise. PF4 has been found to rejuvenate the aging brain, making old mice cognitively sharper and young mice even smarter.
In a trio of papers appearing in Nature, Nature Aging, and Nature Communications on August 16, 2023, two UCSF teams and a team from the University of Queensland (Australia), identify platelet factor 4 (PF4) as a common messenger of each of these interventions.
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